Pregnancy associated plasma protein-A is preferentially expressed in plaque of patients with restenosis
نویسندگان
چکیده
منابع مشابه
Pregnancy-associated plasma protein-A and the vulnerable plaque.
For more than a decade, pregnancy-associated plasma protein-A (PAPP-A) has been examined for its relation to acute coronary syndrome (ACS) and the vulnerable plaque. This review summarizes the current knowledge of plasma PAPP-A in relation to nonpregnant individuals focusing on patients with ACS, discusses its use as a possible biomarker for diagnosis and prognosis in ACS, briefly describes the...
متن کاملPlasma Pregnancy-Associated Plasma Protein A and CD40 are Potential Biomarkers of Vulnerable Plaque Associated with Middle Cerebral Artery Stenosis
Intracranial artery stenosis, especially middle cerebral artery stenosis (MCAS), is prevalent in the Chinese population. Currently, few approaches target evaluating MCAS-associated plaque vulnerability. Herein we aimed to explore potential plasma biomarkers for vulnerable plaque in patients with MCAS. A total of 81 subjects who received microembolic signal (MES) detection were enrolled between ...
متن کاملEffect of Pregnancy Associated Plasma Protein- A Overexpression on Athero- sclerotic Plaque Morphology in Mice
Objective: A novel metalloproteinase, Pregnancy Associated Plasma Protein-A (PAPP-A), has been implicated in the development of atherosclerosis, and is under consideration as a novel biomarker for acute coronary syndrome and unstable plaque. The aim of this study was to determine if PAPP-A overexpression directly contributes to plaque vulnerability. Methods: Apolipoprotein E knock-out (ApoE KO)...
متن کاملComparison of pregnancy-associated plasma protein-A, troponin and creatine kinase-MB levels in acute coronary syndrome
Background: Early diagnosis and proper treatment of patient with acute coronary syndrome (ACS) and ischemic heart disease are important in determining prognosis, preventing adverse effects, and may even save lives. In this study, the level of pregnancy-associated plasma protein-A (PAPP-A) in ACS patients was compared with the control group, in addition to cardiac Troponin (cTn) and creatine kin...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)80083-3